@layer properties{@supports ((-webkit-hyphens:none) and (not (margin-trim:inline))) or ((-moz-orient:inline) and (not (color:rgb(from red r g b)))){*,::backdrop,:after,:before{--tw-rotate-x:initial;--tw-rotate-y:initial;--tw-rotate-z:initial;--tw-skew-x:initial;--tw-skew-y:initial;--tw-border-style:solid;--tw-blur:initial;--tw-brightness:initial;--tw-contrast:initial;--tw-grayscale:initial;--tw-hue-rotate:initial;--tw-invert:initial;--tw-opacity:initial;--tw-saturate:initial;--tw-sepia:initial;--tw-drop-shadow:initial;--tw-drop-shadow-color:initial;--tw-drop-shadow-alpha:100%;--tw-drop-shadow-size:initial}}}@layer theme{:host,:root{--font-sans:ui-sans-serif,system-ui,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji";--font-mono:ui-monospace,SFMono-Regular,Menlo,Monaco,Consolas,"Liberation Mono","Courier New",monospace;--spacing:.25rem;--default-font-family:var(--font-sans);--default-mono-font-family:var(--font-mono)}}@layer base{*,::backdrop,:after,:before{border:0 solid;box-sizing:border-box;margin:0;padding:0}::file-selector-button{border:0 solid;box-sizing:border-box;margin:0;padding:0}:host,html{-webkit-text-size-adjust:100%;font-family:var(--default-font-family,ui-sans-serif,system-ui,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color Emoji");font-feature-settings:var(--default-font-feature-settings,normal);font-variation-settings:var(--default-font-variation-settings,normal);line-height:1.5;-moz-tab-size:4;-o-tab-size:4;tab-size:4;-webkit-tap-highlight-color:transparent}hr{border-top-width:1px;color:inherit;height:0}abbr:where([title]){-webkit-text-decoration:underline dotted;text-decoration:underline dotted}h1,h2,h3,h4,h5,h6{font-size:inherit;font-weight:inherit}a{color:inherit;-webkit-text-decoration:inherit;text-decoration:inherit}b,strong{font-weight:bolder}code,kbd,pre,samp{font-family:var(--default-mono-font-family,ui-monospace,SFMono-Regular,Menlo,Monaco,Consolas,"Liberation Mono","Courier New",monospace);font-feature-settings:var(--default-mono-font-feature-settings,normal);font-size:1em;font-variation-settings:var(--default-mono-font-variation-settings,normal)}small{font-size:80%}sub,sup{font-size:75%;line-height:0;position:relative;vertical-align:baseline}sub{bottom:-.25em}sup{top:-.5em}table{border-collapse:collapse;border-color:inherit;text-indent:0}:-moz-focusring{outline:auto}progress{vertical-align:baseline}summary{display:list-item}menu,ol,ul{list-style:none}audio,canvas,embed,iframe,img,object,svg,video{display:block;vertical-align:middle}img,video{height:auto;max-width:100%}button,input,optgroup,select,textarea{background-color:#0000;border-radius:0;color:inherit;font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;opacity:1}::file-selector-button{background-color:#0000;border-radius:0;color:inherit;font:inherit;font-feature-settings:inherit;font-variation-settings:inherit;letter-spacing:inherit;opacity:1}:where(select:is([multiple],[size])) optgroup{font-weight:bolder}:where(select:is([multiple],[size])) optgroup option{padding-inline-start:20px}::file-selector-button{margin-inline-end:4px}::-moz-placeholder{opacity:1}::placeholder{opacity:1}@supports (not (-webkit-appearance:-apple-pay-button)) or (contain-intrinsic-size:1px){::-moz-placeholder{color:currentColor}::placeholder{color:currentColor}@supports (color:color-mix(in lab,red,red)){::-moz-placeholder{color:color-mix(in oklab,currentcolor 50%,transparent)}::placeholder{color:color-mix(in oklab,currentcolor 50%,transparent)}}}textarea{resize:vertical}::-webkit-search-decoration{-webkit-appearance:none}::-webkit-date-and-time-value{min-height:1lh;text-align:inherit}::-webkit-datetime-edit{display:inline-flex}::-webkit-datetime-edit-fields-wrapper{padding:0}::-webkit-datetime-edit,::-webkit-datetime-edit-year-field{padding-block:0}::-webkit-datetime-edit-day-field,::-webkit-datetime-edit-month-field{padding-block:0}::-webkit-datetime-edit-hour-field,::-webkit-datetime-edit-minute-field{padding-block:0}::-webkit-datetime-edit-millisecond-field,::-webkit-datetime-edit-second-field{padding-block:0}::-webkit-datetime-edit-meridiem-field{padding-block:0}::-webkit-calendar-picker-indicator{line-height:1}:-moz-ui-invalid{box-shadow:none}button,input:where([type=button],[type=reset],[type=submit]){-webkit-appearance:button;-moz-appearance:button;appearance:button}::file-selector-button{-webkit-appearance:button;-moz-appearance:button;appearance:button}::-webkit-inner-spin-button,::-webkit-outer-spin-button{height:auto}[hidden]:where(:not([hidden=until-found])){display:none!important}}@layer components;@layer utilities{.start{inset-inline-start:var(--spacing)}.container{width:100%}@media(min-width:40rem){.container{max-width:40rem}}@media(min-width:48rem){.container{max-width:48rem}}@media(min-width:64rem){.container{max-width:64rem}}@media(min-width:80rem){.container{max-width:80rem}}@media(min-width:96rem){.container{max-width:96rem}}.flex{display:flex}.transform{transform:var(--tw-rotate-x,) var(--tw-rotate-y,) var(--tw-rotate-z,) var(--tw-skew-x,) var(--tw-skew-y,)}.resize{resize:both}.flex-wrap{flex-wrap:wrap}.border{border-style:var(--tw-border-style);border-width:1px}.filter{filter:var(--tw-blur,) var(--tw-brightness,) var(--tw-contrast,) var(--tw-grayscale,) var(--tw-hue-rotate,) var(--tw-invert,) var(--tw-saturate,) var(--tw-sepia,) var(--tw-drop-shadow,)}}:root{--color-bg:#faf9f7;--color-bg-alt:#f0eee9;--color-text:#1a1a1a;--color-text-muted:#6b6560;--color-text-faint:#9b9590;--color-border:#e0ddd8;--color-link:#2c5282;--color-link-hover:#1a365d;--color-accent:#c05621;--color-positive:#276749;--color-negative:#9b2c2c;--color-mixed:#975a16;--color-neutral:#6b6560;--color-hypothesis:#d69e2e;--color-established:#38a169;--color-speculative:#a0aec0;--color-data:#3182ce;--color-rct:#276749;--color-cohort:#2b6cb0;--color-animal:#805ad5;--color-review:#d69e2e;--color-meta:#38a169;--color-invitro:#e53e3e;--color-mechanistic:#dd6b20;--color-case:#718096;--measure:65ch;--space-xs:.25rem;--space-sm:.5rem;--space-md:.75rem;--space-lg:1.25rem;--space-xl:1.75rem;--space-2xl:2.5rem;--font-body:-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,"Helvetica Neue",Arial,sans-serif;--font-mono:"SF Mono","Fira Code","Fira Mono","Roboto Mono",monospace;--radius:4px}@media(prefers-color-scheme:dark){:root{--color-bg:#1a1a1a;--color-bg-alt:#242424;--color-text:#e8e6e3;--color-text-muted:#a09b95;--color-text-faint:#706b65;--color-border:#3a3530;--color-link:#90cdf4;--color-link-hover:#bee3f8;--color-accent:#ed8936}}*{box-sizing:border-box;margin:0;padding:0}html{background:var(--color-bg);color:var(--color-text);font-family:var(--font-body);-webkit-font-smoothing:antialiased;font-size:15px;line-height:1.55}body{min-height:100dvh}h1,h2,h3,h4{font-weight:600;line-height:1.25}h1{font-size:1.6rem}h1,h2{margin-bottom:var(--space-sm)}h2{font-size:1.25rem;margin-top:var(--space-xl)}h3{font-size:1.1rem;margin-top:var(--space-lg)}h3,h4{margin-bottom:var(--space-xs)}h4{font-size:1rem;margin-top:var(--space-md)}p{margin-bottom:var(--space-md);max-width:var(--measure)}a{color:var(--color-link);text-decoration:none}a:hover{color:var(--color-link-hover);text-decoration:underline}blockquote{border-left:3px solid var(--color-accent);color:var(--color-text-muted);margin:var(--space-sm) 0;max-width:var(--measure);padding:var(--space-xs) var(--space-md)}code{background:var(--color-bg-alt);border-radius:var(--radius);font-family:var(--font-mono);font-size:.875em;padding:.1em .3em}ol,ul{margin-bottom:var(--space-md);max-width:var(--measure);padding-left:var(--space-lg)}li{margin-bottom:.15rem}hr{border:none;border-top:1px solid var(--color-border);margin:var(--space-lg) 0}.container{margin:0 auto;max-width:1100px;padding:0 var(--space-md)}.content-body{max-width:var(--measure)}.two-column{display:grid;gap:var(--space-xl);grid-template-columns:1fr 280px}@media(max-width:768px){.two-column{grid-template-columns:1fr}}.site-nav{border-bottom:1px solid var(--color-border);padding:var(--space-sm) 0}.site-nav .container{align-items:center;display:flex;flex-wrap:wrap;gap:var(--space-lg)}.site-nav .logo{color:var(--color-text);font-size:1rem;font-weight:700;text-decoration:none}.site-nav .logo:hover{color:var(--color-accent);text-decoration:none}.site-nav nav{display:flex;gap:var(--space-md)}.site-nav nav a{color:var(--color-text-muted);font-size:.85rem}.site-nav nav a:hover{color:var(--color-text)}.page-header{padding:var(--space-xl) 0 var(--space-lg)}.page-header h1{font-size:1.75rem}.page-header .subtitle{color:var(--color-text-muted);font-size:.95rem;max-width:var(--measure)}.badge{border-radius:var(--radius);display:inline-block;font-size:.65rem;font-weight:600;letter-spacing:.04em;padding:.1em .5em;text-transform:uppercase}.badge-hypothesis{background:var(--color-hypothesis)}@supports (color:color-mix(in lab,red,red)){.badge-hypothesis{background:color-mix(in srgb,var(--color-hypothesis) 20%,transparent)}}.badge-hypothesis{color:var(--color-hypothesis)}.badge-established{background:var(--color-established)}@supports (color:color-mix(in lab,red,red)){.badge-established{background:color-mix(in srgb,var(--color-established) 20%,transparent)}}.badge-established{color:var(--color-established)}.badge-speculative{background:var(--color-speculative)}@supports (color:color-mix(in lab,red,red)){.badge-speculative{background:color-mix(in srgb,var(--color-speculative) 20%,transparent)}}.badge-speculative{color:var(--color-speculative)}.badge-data{background:var(--color-data)}@supports (color:color-mix(in lab,red,red)){.badge-data{background:color-mix(in srgb,var(--color-data) 20%,transparent)}}.badge-data{color:var(--color-data)}.badge-rct{background:var(--color-rct)}@supports (color:color-mix(in lab,red,red)){.badge-rct{background:color-mix(in srgb,var(--color-rct) 20%,transparent)}}.badge-rct{color:var(--color-rct)}.badge-cohort{background:var(--color-cohort)}@supports (color:color-mix(in lab,red,red)){.badge-cohort{background:color-mix(in srgb,var(--color-cohort) 20%,transparent)}}.badge-cohort{color:var(--color-cohort)}.badge-animal{background:var(--color-animal)}@supports (color:color-mix(in lab,red,red)){.badge-animal{background:color-mix(in srgb,var(--color-animal) 20%,transparent)}}.badge-animal{color:var(--color-animal)}.badge-review{background:var(--color-review)}@supports (color:color-mix(in lab,red,red)){.badge-review{background:color-mix(in srgb,var(--color-review) 20%,transparent)}}.badge-review{color:var(--color-review)}.badge-meta-analysis{background:var(--color-meta)}@supports (color:color-mix(in lab,red,red)){.badge-meta-analysis{background:color-mix(in srgb,var(--color-meta) 20%,transparent)}}.badge-meta-analysis{color:var(--color-meta)}.badge-in-vitro{background:var(--color-invitro)}@supports (color:color-mix(in lab,red,red)){.badge-in-vitro{background:color-mix(in srgb,var(--color-invitro) 20%,transparent)}}.badge-in-vitro{color:var(--color-invitro)}.badge-mechanistic{background:var(--color-mechanistic)}@supports (color:color-mix(in lab,red,red)){.badge-mechanistic{background:color-mix(in srgb,var(--color-mechanistic) 20%,transparent)}}.badge-mechanistic{color:var(--color-mechanistic)}.badge-case-report{background:var(--color-case)}@supports (color:color-mix(in lab,red,red)){.badge-case-report{background:color-mix(in srgb,var(--color-case) 20%,transparent)}}.badge-case-report{color:var(--color-case)}.badge-positive{background:var(--color-positive)}@supports (color:color-mix(in lab,red,red)){.badge-positive{background:color-mix(in srgb,var(--color-positive) 20%,transparent)}}.badge-positive{color:var(--color-positive)}.badge-negative{background:var(--color-negative)}@supports (color:color-mix(in lab,red,red)){.badge-negative{background:color-mix(in srgb,var(--color-negative) 20%,transparent)}}.badge-negative{color:var(--color-negative)}.badge-mixed{background:var(--color-mixed)}@supports (color:color-mix(in lab,red,red)){.badge-mixed{background:color-mix(in srgb,var(--color-mixed) 20%,transparent)}}.badge-mixed{color:var(--color-mixed)}.badge-neutral{background:var(--color-neutral)}@supports (color:color-mix(in lab,red,red)){.badge-neutral{background:color-mix(in srgb,var(--color-neutral) 20%,transparent)}}.badge-neutral{color:var(--color-neutral)}.card{background:var(--color-bg);border:1px solid var(--color-border);border-radius:var(--radius);padding:var(--space-md);transition:border-color .15s}.card:hover{border-color:var(--color-text-faint)}.card-title{font-size:.9rem;font-weight:600;line-height:1.3;margin-bottom:.15rem}.card-title a{color:var(--color-text)}.card-title a:hover{color:var(--color-link);text-decoration:none}.card-meta{display:flex;flex-wrap:wrap;font-size:.75rem;gap:var(--space-sm);margin-bottom:var(--space-xs)}.card-description,.card-meta{color:var(--color-text-muted)}.card-description{font-size:.8rem;line-height:1.45}.card-chips{display:flex;flex-wrap:wrap;gap:var(--space-xs);margin-top:var(--space-xs)}.chip{background:var(--color-bg-alt);border-radius:var(--radius);color:var(--color-text-muted);display:inline-block;font-size:.65rem;padding:.1em .45em}.chip,.chip:hover{text-decoration:none}.chip:hover{background:var(--color-border);color:var(--color-text)}.filter-bar{display:flex;flex-wrap:wrap;gap:.3rem;margin-bottom:var(--space-sm)}.filter-chip{background:0 0;border:1px solid var(--color-border);border-radius:100px;color:var(--color-text-muted);cursor:pointer;font-size:.7rem;padding:.2em .6em;transition:all .15s}.filter-chip:hover{border-color:var(--color-text-faint);color:var(--color-text)}.filter-chip.active{background:var(--color-text);border-color:var(--color-text);color:var(--color-bg)}.sidebar{font-size:.8rem}.sidebar section{margin-bottom:var(--space-lg)}.sidebar dt{color:var(--color-text-faint);font-size:.7rem;font-weight:600;letter-spacing:.05em;margin-top:var(--space-xs);text-transform:uppercase}.sidebar dd{margin-bottom:.15rem;margin-left:0}.pathway-card{border-left:2px solid var(--color-border);padding:var(--space-sm) var(--space-md);transition:border-color .15s}.pathway-card:hover{border-color:var(--color-accent)}.pathway-card .study-count{color:var(--color-text-faint);font-size:.75rem}.citation-ref{color:var(--color-link);cursor:pointer;font-size:.8em;font-weight:600;vertical-align:super}.citation-popover{background:var(--color-bg);border:1px solid var(--color-border);border-radius:var(--radius);box-shadow:0 4px 12px #0000001a;font-size:.8rem;max-width:400px;padding:var(--space-md);position:absolute;z-index:50}.form-group{margin-bottom:var(--space-md)}.form-group label{color:var(--color-text-muted);display:block;font-size:.8rem;font-weight:600;margin-bottom:.15rem}.form-group input,.form-group select,.form-group textarea{background:var(--color-bg);border:1px solid var(--color-border);border-radius:var(--radius);color:var(--color-text);font-family:var(--font-body);font-size:.85rem;padding:var(--space-xs) var(--space-sm);width:100%}.form-group textarea{min-height:80px;resize:vertical}.form-group input:focus,.form-group textarea:focus{border-color:var(--color-link);outline:none}.btn{border:1px solid #0000;border-radius:var(--radius);cursor:pointer;display:inline-block;font-size:.85rem;font-weight:600;padding:var(--space-xs) var(--space-md);transition:all .15s}.btn-primary{background:var(--color-text);color:var(--color-bg)}.btn-primary:hover{opacity:.85}.study-grid{display:grid;gap:var(--space-sm)}.pathway-grid{display:grid;gap:var(--space-xs)}.site-footer{border-top:1px solid var(--color-border);color:var(--color-text-faint);font-size:.75rem;margin-top:var(--space-2xl);padding:var(--space-md) 0}.prose{max-width:var(--measure)}.prose h2{margin-top:var(--space-xl)}.prose h3{margin-top:var(--space-lg)}.prose ol,.prose p,.prose ul{margin-bottom:var(--space-md)}.prose a{text-decoration:underline;text-underline-offset:2px}.prose strong{font-weight:600}.prose table{border-collapse:collapse;font-size:.85rem;margin:var(--space-sm) 0;width:100%}.prose td,.prose th{border:1px solid var(--color-border);padding:var(--space-xs) var(--space-sm);text-align:left}.prose th{background:var(--color-bg-alt);font-weight:600}@property --tw-rotate-x{syntax:"*";inherits:false}@property --tw-rotate-y{syntax:"*";inherits:false}@property --tw-rotate-z{syntax:"*";inherits:false}@property --tw-skew-x{syntax:"*";inherits:false}@property --tw-skew-y{syntax:"*";inherits:false}@property --tw-border-style{syntax:"*";inherits:false;initial-value:solid}@property --tw-blur{syntax:"*";inherits:false}@property --tw-brightness{syntax:"*";inherits:false}@property --tw-contrast{syntax:"*";inherits:false}@property --tw-grayscale{syntax:"*";inherits:false}@property --tw-hue-rotate{syntax:"*";inherits:false}@property --tw-invert{syntax:"*";inherits:false}@property --tw-opacity{syntax:"*";inherits:false}@property --tw-saturate{syntax:"*";inherits:false}@property --tw-sepia{syntax:"*";inherits:false}@property --tw-drop-shadow{syntax:"*";inherits:false}@property --tw-drop-shadow-color{syntax:"*";inherits:false}@property --tw-drop-shadow-alpha{syntax:"<percentage>";inherits:false;initial-value:100%}@property --tw-drop-shadow-size{syntax:"*";inherits:false}
