Melatonin plays a key role in intracellular membrane integrity, especially when a cell is in under stress. Melatonin plays role in maintaining a high ATP:ADP ratio, which suppresses glycolysis. Supplemental melatonin shown to accumulate in all cells, accumulates 10x in membrane compared to mitochondria. Plays unique role in fat/water interfaces, as it can combine with both. Biomolecular condensates play a big role in brain disorders and are shaped by complex relationships between membraneless organelles, membranes/lipid rafts, ATP, RNA, and most of all, stress. Melatonin’s intimate association with each of these decisive influencers may position it as an important mediator of sorting out of these condensates in health and disease via ATP-dependent mechanisms.