NA activates the capsaicin receptor TRPV1 by lowering the activation threshold for heat, causing channel activation at physiological body temperature. Conversely it inhibits TRPV4 by raising activation temp to above body temp, ~41 celsius. Overall, the effects on TRPV1 and TRPV3 are potentiating while those on TRPV2 and TRPV4 are inhibitory. Little is known about the detailed structures of TRPV2-4. The TRPV receptors play a role in the flushing response.