Review of many clinical trials concludes niacin supplementation can improve lipid profiles without affecting the glycemic levels for patients with Type 2 diabetes.
Rats where split into 2 groups, one group was injected with a single does of streptozotocin at a dose of 60 mg/kg body weight, which is a chemical that is used to induce diabetes. After 12 weeks it was found that the diabetes group was only able to convert half as much tryptophan to niacins as the control group. The rats in the diabetic group had twice the excretion of xanthurenic acid in their urine. Xanthurenic acid is a waste product that is produced when tryptophan is not converted into niacin.
Rats in group 1 received no treatment. Rats in group 2 received daily 100 mg/kg body weight niacin injections. Rats in group 3 received daily 50 mg/kg body weight vitamin C injections. Rats in group 4 received both niacin and vitamin C injections. Blood sugar levels were measured before and after treatment. The results showed that niacin and vitamin C both lowered blood sugar levels in normal rats. Niacin was more effective than vitamin C in lowering blood sugar levels in diabetic rats. The combination of niacin and vitamin C was the most effective in lowering blood sugar levels in diabetic rats.
24 healthy men and women with a mean age of 35 years, where injected Intravenously w/ 1g of niacin or placebo for 2 weeks. The niacin group ended up with acutely lower levels of FFAs (free fatty acids, fats floating around in the bloodstream) and significantly higher levels of triglyceride stored in visceral adipose tissue. This may help to reduce the amount of fat that is stored in the liver and other organs, which can help to improve insulin sensitivity and reduce the risk of metabolic complications. IE niacin may help people with diabetes and obesity to lose weight and improve their health.
Most "niacin" products are niacinamide. If you want the form discussed in this research, look for nicotinic acid specifically.
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