Posts | Niacin.io

Vitamin b3 and Seborrheic dermatitis - a phase IV clinical study of FDA data

Study of 4,269 people that take niacin or have Seborrheic dermatitis finds no cases of Seborrheic dermatitis in people who take niacin.

Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain

Summary of GPR109A (niacin receptor) role in inflammation of the nervous system, especially the brain, and how activation of GPR109A plays a role in healing may conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, stroke, and pathological pain.

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock

Niacin improves organ function and survival following hemorrhagic shock. Rats and mice where bled 60% of their blood volume, and replaced with Ringers lactate solution to induce hemorrhagic shock ( deprive tissue of oxygen and blood ). After 10 minutes of shock the animals where split into 3 groups and injected with nicotinic acid, NMN or DMSO, at 3 levels of dosing. Niacin at 10mg/kg, which was the highest dose given, had by far the best level of survivability. Rats, given NMN even at a 5x higher dose than niacin at 50mg/kg did not achieve a survival rate to the level observed in the 10mg/kg or the even 5mg/kg treated mice. Use of GPR109A knockout mice confirmed that the niacin GPR109A receptor plays a major role in the survivability enhancing effect of niacin.

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration

Axon degeneration from NMN accumulation can be prevented by bypassing the NAD+ salvage pathway (which is associated with the production of NMN) by providing nicotinic acid riboside (a precursor to nicotinic acid mononucleotide) as substrate for the body to make NAD+ via the primary Preiss Handler pathway instead.