25 individuals with CKD (chronic kidney disease) stages 2-4 treated with a combination of supplements, including 500mg niacin 3x/day for three months, improved the disease by at least one stage.
Read NotesAuthors hypothesis that antidepressants tilt tryptophan metabolism towards making serotonin instead of niacin, which in turn can lead to niacin/NAD+ deficiency that exacerbates common psychiatric problems.
Dogs with severe niacin deficiency required folic acid to be administered in tandem with niacin in order to recover and avoid death.
Nicotinic acid mimics the effect of a ketogenic diet in activating HCA2, which induces a neuroprotective phenotype in bone marrow-derived macrophages that infiltrate the brain and that this results in an improved outcome in a mouse model of stroke.
Most "niacin" products are niacinamide. If you want the form discussed in this research, look for nicotinic acid specifically.
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