fertility
Studies (5)
Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice
A study in mice found that niacin supplementation increased NAD+ levels in the testes, which led to an improvement in sperm count and sperm motility. NAD+ deficient mice have ~30% smaller testes (balls) than the control mice (~1.5g vs ~2.17g). NAD+ is essential for spermatogenesis and that NAD+ deficiency leads to male infertility.
A prospective and comparative investigation of blood sFlt-1, P1GF, and niacin concentrations in women with premature ovarian insufficiency
Niacin supplementation may prevent premature menopause. Women with premature menopause have significantly lower levels of niacin. Niacin levels lowest in women most severe symptoms.
NAD+ repletion rescues female fertility during reproductive aging
Loss of fertility is associated with lower NAD+ levels. Restoring NAD+ in aged mice by putting nicotinamide mononucleotide (NMN) in their drinking water at 2g/L restored their fertility as well as the adverse effect of old age on the development of the embryo.
Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats
Feeding normal and diabetic rats 800mg of niacin per kg of diet increased testicular weight in all rats and decreased testicular MDA (a biomarker for cancer). Normal rats, but not diabetic ones, also had an increase in sperm count and serum testosterone.
NAD Deficiency, Congenital Malformations, and Niacin Supplementation
Disruption of NAD synthesis caused a deficiency of NAD and birth defects in humans and mice. Niacin supplementation during pregnancy prevented the birth defects in mice.