dermatitis
Pathways
Studies (5)
Dyssebacia: An Early Cutaneous Marker of Niacin Deficiency
Dyssebacia ( reddening, greasy, flaky scales often around nose and mouth ) is a sign of niacin deficiency.
Vitamin b3 and Seborrheic dermatitis - a phase IV clinical study of FDA data
Study of 4,269 people that take niacin or have Seborrheic dermatitis finds no cases of Seborrheic dermatitis in people who take niacin.
Acne Vulgaris Is a Special Clinical Type of Pellagra
People with acne often have abnormal lipid profiles and elevated oily secretion on their skin. Foam cells are an important pathological change in acne lesions. Acne is not a skin disease induced by infection, because no bacteria, fungi or parasites can be seen in early phase of acne lesion. The foam cells in acne lesions are white blood cells that have ingested large amounts of lipids. Niacin is the only vitamin that promotes the ability of HDL to scoop up cholesterol particles from plaques in the heart's blood vessels and move those particles to the liver for disposal, which prevents foam cell formation. Foam cells in acne lesions suggest that patients with acne are deficient in niacin and that acne can be considered a type of pellagra (niacin deficiency).
Supplementation of nicotinic acid and its derivatives up-regulates cellular NAD+ level rather than nicotinamide derivatives in cultured normal human epidermal keratinocytes
In cultured skin cells, nicotinic acid supplementation 1.3-fold up-regulated intracellular NAD+ level significantly and its metabolites nicotinic acid mono nucleotide also increased NAD+ level by 1.5-fold with 100 μM application. Surprisingly, NAM and its derivatives could not up-regulate cellular NAD+ levels in keratinocytes.
Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate
Psoriatic skin has reduced GPR109A expression, topical sodium butyrate increases GPR109A expression in skin and is potentially useful in psoriasis therapy.