dyslipidemia
Pathways
Studies (9)
Effects of dietary nicotinic acid supplementation on meat quality, carcass characteristics, lipid metabolism, and tibia parameters of Wulong geese
Feeding geese nicotnic acid improves muscle & fat tone, bone density, lipid metabolism. 80mg/kg per day was found to be optimal dose for improving quality of geese tibia ( longest bone in leg ).
Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials
Review of many clinical trials concludes niacin supplementation can improve lipid profiles without affecting the glycemic levels for patients with Type 2 diabetes.
Nicotinic Acid Treatment Shifts the Fibrinolytic Balance Favourably and Decreases Plasma Fibrinogen in Hypertriglyceridaemic Men
23 hypertriglyceridaemic men took 4g/day of niacin for 6 weeks and saw very significant improvements in lipoprotein concentrations (reducing very low density cholesterol and triglycerides by ~50%) as well as reduced blood clotting and thrombosis factors.
Acne Vulgaris Is a Special Clinical Type of Pellagra
People with acne often have abnormal lipid profiles and elevated oily secretion on their skin. Foam cells are an important pathological change in acne lesions. Acne is not a skin disease induced by infection, because no bacteria, fungi or parasites can be seen in early phase of acne lesion. The foam cells in acne lesions are white blood cells that have ingested large amounts of lipids. Niacin is the only vitamin that promotes the ability of HDL to scoop up cholesterol particles from plaques in the heart's blood vessels and move those particles to the liver for disposal, which prevents foam cell formation. Foam cells in acne lesions suggest that patients with acne are deficient in niacin and that acne can be considered a type of pellagra (niacin deficiency).
A comparison of the efficacy and toxic effects of sustained vs immediate-release niacin in hypercholesterolemic patients
The effects on cholesterol of modified "sustained release" niacin was compared to immediate release niacin (aka nicotinic acid) and showed that sustained release tends to lower LDL more, while immediate release raises HDL more at all dosage levels. The key takeway though is that 52% of the patients taking sustained release developed signs of liver toxixity, while 0% of the ones taking immediate release did.
Niacin reduces abdominal fat: pilot study
Participants in an open label study at Kaiser Permanente in San Francisco supplemented ~3g niacin a day. After about 1 year, 81% of patients had an by an average reduction of 27% in intra-abdominal fat. The degree of fat loss was associated with the degree of increase in HDL cholesterol and a reduced Total Cholesterol/HDL cholesterol ratio.
Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice
Low dose niacin (50 mg/kg diet and 250 mg/kg diet) when supplemented in combination with leucine (24 g/kg diet) has a similar effect on lowering cholesterol in mice than standard therapeutic dose (1000 mg/kg diet) of niacin without leucine supplementation. Leucine amplifies niacin effect on lipid metabolism, hyperlipidemia and atherosclerosis in mice, at least in part by activation of the AMPK/Sirt1 axis.
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
9 years after the conclusion of a long term study on various drugs to reduce risk of death of people who had a heart attack, only the niacin group showed a statistically significant, 11% reduction in mortality than in the placebo group. This was after they stopped taking the niacin 9 years earlier, indicating a long term benefit.
New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders
An overview of research showing supplementing niacin lowers the risk of heart attack frequency and severity.