apoptosis
Studies (6)
Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation
This study grafted malignant gliomas cells (which are one of the most common types of primary brain tumors) into rat brains to see if nicotinic acid administration would help regulate the implanted tumor. ~70% of the allografted rats that were continuously administered with nicotinic acid were still alive on day 58. 100% of control group died by day 24. Biopsy showed much less tumor spread in nicotinic acid rats. Their results suggest that niacin the helps prevent the invasion of other kinds of malignant cells such as melanoma ( skin cancer ) cells and that this points to a general role of nicotinic acid in regulating tumor invasion.
Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism
Curcumin is an anticancer agent, it has demonstrates potent anti-proliferative activity in a wide range of cancer cells, including liver, breast, lung, stomach, colon, prostate, head and neck cancers. This study modified curcumin by adding 2 niacins molecules to it to make Curcumin Nicotinate. They tested it out on some cancer cell cultures and it showed that the Curcumin Nicotinate improved the anti cancer effect of curcumin by improving its cell selectivity.
Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes
Niacin pretreatment of skin cells protects against UV-induced cell death and apoptosis by enhancing the pro-survival pathways including AKT, mTOR and S6 in skin keratinocytes. Oral and external niacin is safe and appears to be a promising chemo-preventive supplement for reducing the mutagenic, immunosuppressive and cell damage effects of sunlight. This is also the first study providing a molecular mechanism to support that niacin can be utilized as a skin photo-damage protective agent.
The Niacin/Butyrate Receptor GPR109A Suppresses Mammary Tumorigenesis by Inhibiting Cell Survival
The expression of niacin receptor GPR109A is decreased by over 70% in breast cancer samples. It's reduced in early stages, and almost undetectable in advanced stages. Increasing expression of GPR109A seems to act as a tumor suppressor in breast tissue, but interestingly can also acts as tumor protective in other tissues like skin, mechanism of differentiation unknown.
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
Supplementing melatonin is safe. Melatonin is a potent anti-oxidant and anti-inflammatory agent, it's found in all cells and can easily cross all physiological barriers in body. Melatonin levels decreases with age. Melatonin therapy looks promising for a wide range of health issues in newborn babies.
Open AccessReview Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects
Overview of how niacin and its metabolites like NAD, NADP, NADPH play a key role in cellular signaling, apoptosis, balancing intestinal flora and gene expression. Without external supply of supply of niacin, the genome becomes unstable via the antioxidant system no longer functioning efficiently, which ultimately leads to cell death.