obesity
Studies (10)
Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention
In 58 patients with fatty liver disease, the ones with the most niacin in their diet had the most favorable outcome, with a 37% reduction in liver fat after 9 months of lifestyle interventions, vs only 10% reduction in the patients eating the least niacin.
Intravenous Niacin Acutely Improves the Efficiency of Dietary Fat Storage in Lean and Obese Humans
24 healthy men and women with a mean age of 35 years, where injected Intravenously w/ 1g of niacin or placebo for 2 weeks. The niacin group ended up with acutely lower levels of FFAs (free fatty acids, fats floating around in the bloodstream) and significantly higher levels of triglyceride stored in visceral adipose tissue. This may help to reduce the amount of fat that is stored in the liver and other organs, which can help to improve insulin sensitivity and reduce the risk of metabolic complications. IE niacin may help people with diabetes and obesity to lose weight and improve their health.
Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid
Gut bacteria play an important role in NAD production. NAD boosting effect of oral NAM (nicotinamide) NR (nicotinamide riboside) is largely dependent on gut bacteria breaking them down to nicotinic acid, and that nicotinic acid being processed via Preiss Handler pathway. Nicotinic acid highly efficient at boosting NAD in mammals.
Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes
Niacin reduces inflammation caused by low levels of oxygen in tissue that is associated with obesity.
Niacin reduces abdominal fat: pilot study
Participants in an open label study at Kaiser Permanente in San Francisco supplemented ~3g niacin a day. After about 1 year, 81% of patients had an by an average reduction of 27% in intra-abdominal fat. The degree of fat loss was associated with the degree of increase in HDL cholesterol and a reduced Total Cholesterol/HDL cholesterol ratio.
Melatonin supplementation ameliorates myocardial connexin-43 disorders and arrhythmia risk of hypertensive and obese rats
Melatonin supplementation benefits male hypertensive and female obese rats due to suppression of metabolic disorders and lethal arrhythmia risk. Arrhythmia is a problem with the rate or rhythm of your heartbeat. Protection against arrhythmia may attributed, at least in part, to up-regulation of myocardial Cx43, which is a protein that is essential for the formation of heart structures.
Anti-inflammatory effects of nicotinic acid
Niacin has multi-faceted anti inflammatory properties that act in both localized and systemic ways. A major area of its activity is in tissue related to fat storage via the GPR109A receptor. Dosing cells with TNF-alpha ( an inflammatory substance ) showed that niacin treated cells increased the atheroprotective hormone adiponectin and reduced macrophage chemotaxis
Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models
Rats where given unlimited access to food and a controlled amount of exercise. Those taking niacin + melatonin lost statistically significantly more weight, compared to control, niacin only and melatonin only groups. Suggests a synergy between niacin & melatonin supplementation for anti-obesity. It's noted that mice lacking the niacin receptor GPR109A had progressive weight gain and liver fat accumulation.
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
Adipose tissue (body tissue used for the storage of fat) is major site of action for niacin. When adding a white blood cell attractant to adipose tissue, niacin suppresses the pro-atherogenic (plaque inducing) chemokines and upregulates the atheroprotective (protective against plaque and improves metabolism of sugar) adiponectin.
Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
When fed a high fat diet + niacin, mice deficient in niacin receptor GPR109A got fat and had fatty livers. While mice with normal GPR109A receptors didn't get fat and didn't end up with fatty livers.