insulin-resistance
Studies (5)
Effects of Niacin and Vitamin C on Blood Sugar
Rats in group 1 received no treatment. Rats in group 2 received daily 100 mg/kg body weight niacin injections. Rats in group 3 received daily 50 mg/kg body weight vitamin C injections. Rats in group 4 received both niacin and vitamin C injections. Blood sugar levels were measured before and after treatment. The results showed that niacin and vitamin C both lowered blood sugar levels in normal rats. Niacin was more effective than vitamin C in lowering blood sugar levels in diabetic rats. The combination of niacin and vitamin C was the most effective in lowering blood sugar levels in diabetic rats.
Intravenous Niacin Acutely Improves the Efficiency of Dietary Fat Storage in Lean and Obese Humans
24 healthy men and women with a mean age of 35 years, where injected Intravenously w/ 1g of niacin or placebo for 2 weeks. The niacin group ended up with acutely lower levels of FFAs (free fatty acids, fats floating around in the bloodstream) and significantly higher levels of triglyceride stored in visceral adipose tissue. This may help to reduce the amount of fat that is stored in the liver and other organs, which can help to improve insulin sensitivity and reduce the risk of metabolic complications. IE niacin may help people with diabetes and obesity to lose weight and improve their health.
Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models
Rats where given unlimited access to food and a controlled amount of exercise. Those taking niacin + melatonin lost statistically significantly more weight, compared to control, niacin only and melatonin only groups. Suggests a synergy between niacin & melatonin supplementation for anti-obesity. It's noted that mice lacking the niacin receptor GPR109A had progressive weight gain and liver fat accumulation.
Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Studies show that melatonin ameliorates hyperinsulinemia, insulin resistance, and insulin sensitivity.
Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
When fed a high fat diet + niacin, mice deficient in niacin receptor GPR109A got fat and had fatty livers. While mice with normal GPR109A receptors didn't get fat and didn't end up with fatty livers.