melatonin
Pathways
Studies (4)
Plasma melatonin levels in psoriasis
People with psoriasis tend to have lower levels of melatonin than average at 2 a.m and higher than average at 6am, 8 am & noon.
TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level
The role of TRPV4 channel present in human ciliary body epithelial cells in AANAT production was studied. AANAT, Aralkylamine N-acetyltransferase seems to be the key enzyme involved in producing melatonin from serotonin. In rodents, transcriptional activation of aanat gene is the classical mechanism to induce melatonin biosynthesis. TRPV4 is present in the human ciliary body and ciliary body epithelial cells. Activating TRPV4 channel increases the expression of AANAT, which elevates the concentration of NAS and melatonin
Physiological and Anti-obesity Effects of Melatonin and Niacin Supplements in Rat Models
Rats where given unlimited access to food and a controlled amount of exercise. Those taking niacin + melatonin lost statistically significantly more weight, compared to control, niacin only and melatonin only groups. Suggests a synergy between niacin & melatonin supplementation for anti-obesity. It's noted that mice lacking the niacin receptor GPR109A had progressive weight gain and liver fat accumulation.
Gut melatonin: A potent candidate in the diversified journey of melatonin research
This paper investigates the production melatonin in the gut, notably it being unrelated to the day/light cycle and how eating patterns affect its production, and what the produced melatonin may be used for.