Research on niacin and ADP

• Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders

  Melatonin plays a key role in intracellular membrane integrity, especially when a cell is in under stress. Melatonin plays role in maintaining a high ATP:ADP ratio, which suppresses glycolysis. Supplemental melatonin shown to accumulate in all cells, accumulates 10x in membrane compared to mitochondria. Plays unique role in fat/water interfaces, as it can combine with both. Biomolecular condensates play a big role in brain disorders and are shaped by complex relationships between membraneless organelles, membranes/lipid rafts, ATP, RNA, and most of all, stress. Melatonin’s intimate association with each of these decisive influencers may position it as an important mediator of sorting out of these condensates in health and disease via ATP-dependent mechanisms.

• The oxidative stress-induced niacin sink (OSINS) model for HIV pathogenesis

  Talks about how intracellular niacin depletion along leads to tryptophan depletion as the body attempts to compensate by synthesizing niacin from tryptophan. And how this imbalance impairs the immune system in HIV.

• Pharmacological Intakes of Niacin Increase Bone Marrow Poly(ADP-Ribose) and the Latency of Ethylnitrosourea-Induced Carcinogenesis in Rats

  Rats fed high niacin diet and then poisoned with ethylnitrosourea (a potent mutagen) survived for longer and had increase amounts of NAD+ (1-1.5x) and ADP-ribose in their bone marrow.